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In the latest version, pagelayout.aspx no longer has the Panes side by side. They are now stacked vertically.
As covered in the Misc section of the release notes for 22.214.171.124, you must view the Skinning Changes thread here for new classes required for the PageLayout to work correctly.
Thanks, Joe! I had searched the release notes before posting, but it didn't come up because of a small typo.
"revamp of PageLaout.aspx thanks to Joe Davis"