I personally have not tested beyond the Mono 220.127.116.11 VMWare image as of yet. I guess pretty soon I will get the latest VMWare image.
I will say that I am close to a new release of mojoPortal and there are changes in mojoportal svn trunk that were made later than version 18.104.22.168 specifically to solve some issues under Mono.
I was contacted by Marc Christensen of Novell who maintains the RPM package of mojoPortal that they ship with the VMWare iamges about some issues he was having compiling and running mojoPortal so a few minor changes were made with conditional compilation to get around these issues. So the RPM version of mojoPortal shipping with the new mono releases is actually a snapshot of mojoPortal 22.214.171.124 as it existed in svn trunk on the day he made the latest package.
So you may want to try again after the coming mojoPortal release or else by getting the mojoportal code from our svn trunk and building the mojoportal.mds with MonoDevelop