Just to confirm I was able to clone from GitHub and build and run without any problems (using VS2013 Premium).
The README.VisualStudio.txt file needs some tweaks now (re Tortoise etc), and it was all rather mysterious where the DB connection strings should go - could do with a little explanation about what it uses on startup and how a new site is created, and when a user.config comes into play.
I cannot seem to either commit changes or create a pull request using the GitHub for Windows client. It's late!
But overall it worked - nice one.