Hi Shaun,

Yes its possible. You need to study the rendered markup to find css class names you can use to achieve it.

For example if I want the background of modules in the left pane to  be different I can do something like this:

.leftside .modulecontent {background-color: yellow;}

You would want to put these changes near the bottom of your css file so they override any setting above.

Hope it helps,

Joe