Responsive design is a CSS technique, any CSS technique can be used in mojoPortal.
I guess you are talking about a single page application, there is nothing in mojoPortal to help you with that kind of application, I think one could deploy such an app along with mojoPortal but unless you are using mojoPortal for other parts of a larger site then there may not be any benefit to using mojoPortal for project whose main purpose is a single page application.