Hi!
I just want to share the farm configuration I use with mojoPortal and also other CMS-systems.
I did the infrastructure design for a web-hotel and they now run over 600 websites in this configuration and has done so for more than a year now and it works absolutely great!
There are 2 very powerful physical 2008 R2/IIS 7.5 webservers running in a NLB-cluster. 10 IP-adresses are load-balanced and also there are FTP-sites for each customer that are running in the same NLB-cluster, but with single node failover mode.
Data are replicated between the servers with File Replication Service.
So nice, just upload files to any node and they are instantly replicated across.
mojoportal works flawlessly in this configuration. Some DNN-sites had problems because of some caching issues so the site on one node where not aware of new files that had replicated there, but the DNN-guys fixed that (not sure about what was the problem).
FRS is really nice and with a dedicated Gb-network between the nodes it is rellay quick as well and handles all kind of conflicts.
This is a rather special infrastructure setup and we have created a comprehensive set of custom managing-scripts so they can easily provision new sites and force replication and so on.
/Mats